1ow0: Difference between revisions
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'''Crystal structure of human FcaRI bound to IgA1-Fc'''<br /> | '''Crystal structure of human FcaRI bound to IgA1-Fc'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1OW0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1OW0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OW0 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: immunoglobulin-like domain]] | [[Category: immunoglobulin-like domain]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:36:32 2008'' | ||
Revision as of 17:36, 15 February 2008
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Crystal structure of human FcaRI bound to IgA1-Fc
OverviewOverview
Immunoglobulin-alpha (IgA)-bound antigens induce immune effector responses, by activating the IgA-specific receptor FcalphaRI (CD89) on immune cells., Here we present crystal structures of human FcalphaRI alone and in a, complex with the Fc region of IgA1 (Fcalpha). FcalphaRI has two, immunoglobulin-like domains that are oriented at approximately right, angles to each other. Fcalpha resembles the Fcs of immunoglobulins IgG and, IgE, but has differently located interchain disulphide bonds and external, rather than interdomain N-linked carbohydrates. Unlike 1:1 FcgammaRIII:IgG, and Fc epsilon RI:IgE complexes, two FcalphaRI molecules bind each Fcalpha, dimer, one at each Calpha2-Calpha3 junction. The FcalphaRI-binding site on, IgA1 overlaps the reported polymeric immunoglobulin receptor, (pIgR)-binding site, which might explain why secretory IgA cannot initiate, phagocytosis or bind to FcalphaRI-expressing cells in the absence of an, integrin co-receptor.
About this StructureAbout this Structure
1OW0 is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc., Herr AB, Ballister ER, Bjorkman PJ, Nature. 2003 Jun 5;423(6940):614-20. Epub 2003 May 21. PMID:12768205
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