1nvw: Difference between revisions

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[[Image:1nvw.jpg|left|200px]]
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{{STRUCTURE_1nvw|  PDB=1nvw  |  SCENE=  }}  
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'''Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS'''
===Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS===




==Overview==
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Growth factor receptors activate Ras by recruiting the nucleotide exchange factor son of sevenless (SOS) to the cell membrane, thereby triggering the production of GTP-loaded Ras. Crystallographic analyses of Ras bound to the catalytic module of SOS have led to the unexpected discovery of a highly conserved Ras binding site on SOS that is located distal to the active site and is specific for Ras.GTP. The crystal structures suggest that Ras.GTP stabilizes the active site of SOS allosterically, and we show that Ras.GTP forms ternary complexes with SOS(cat) in solution and increases significantly the rate of SOS(cat)-stimulated nucleotide release from Ras. These results demonstrate the existence of a positive feedback mechanism for the spatial and temporal regulation of Ras.
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==Disease==
==Disease==
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[[Category: Guanine-nucleotide releasing factor]]
[[Category: Guanine-nucleotide releasing factor]]
[[Category: Proto-oncogene]]
[[Category: Proto-oncogene]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:02:35 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:11:54 2008''

Revision as of 07:12, 29 July 2008

File:1nvw.png

Template:STRUCTURE 1nvw

Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOSStructural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS

Template:ABSTRACT PUBMED 12628188

DiseaseDisease

Known disease associated with this structure: Fibromatosis, gingival OMIM:[182530], Noonan syndrome 4 OMIM:[182530]

About this StructureAbout this Structure

1NVW is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS., Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, Bar-Sagi D, Kuriyan J, Cell. 2003 Mar 7;112(5):685-95. PMID:12628188

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