1ndv: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1ndv.jpg|left|200px]]
+{{Seed}}
+[[Image:1ndv.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1ndv|  PDB=1ndv  |  SCENE=  }}
-'''Crystal Structure of Adenosine Deaminase complexed with FR117016'''
+===Crystal Structure of Adenosine Deaminase complexed with FR117016===
-==Overview==
+<!--
-We disclose herein the rapid discovery of the first highly potent (Ki = 7.7 nM) non-nucleoside adenosine deaminase (ADA) inhibitor based on the rational hybridization of two structurally distinct leads. Two micromolar inhibitors were discovered by a parallel rational design and random screening program, and individual crystal structures of bovine ADA in complexation with these inhibitors revealed several unknown binding sites and distinct binding modes. Using this information as the starting point, highly effective lead hybridization was achieved in only two structure-based drug design iterations. The conceptual approach illustrated by this example promises to be broadly useful in the search for new chemical entities and can contribute greatly to improve the overall efficiency and speed of drug discovery.
+The line below this paragraph, {{ABSTRACT_PUBMED_14709046}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14709046 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14709046}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Inhibitor-induced conformational change]]
 [[Category: Structure-based drug design]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:25:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:32:51 2008''