1n95: Difference between revisions

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{{STRUCTURE_1n95|  PDB=1n95  |  SCENE=  }}  
{{STRUCTURE_1n95|  PDB=1n95  |  SCENE=  }}  


'''Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives'''
===Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives===




==Overview==
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Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. Clinical trials to evaluate these agents in humans are ongoing. In our effort to develop new farnesyltransferase inhibitors, we have discovered a series of aryl tetrahydropyridines that incorporate substituted glycine, phenylalanine and histidine residues. The design, synthesis, SAR and biological properties of these compounds will be discussed.
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{{ABSTRACT_PUBMED_12657282}}


==About this Structure==
==About this Structure==
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[[Category: Histidine tetrahydropyridine]]
[[Category: Histidine tetrahydropyridine]]
[[Category: Prenyltransferase]]
[[Category: Prenyltransferase]]
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