1n69: Difference between revisions

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-[[Image:1n69.gif|left|200px]]
+{{Seed}}
+[[Image:1n69.png|left|200px]]
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 {{STRUCTURE_1n69|  PDB=1n69  |  SCENE=  }}
-'''Crystal structure of human saposin B'''
+===Crystal structure of human saposin B===
-==Overview==
+<!--
-Saposin B is a small, nonenzymatic glycosphingolipid activator protein required for the breakdown of cerebroside sulfates (sulfatides) within the lysosome. The protein can extract target lipids from membranes, forming soluble protein-lipid complexes that are recognized by arylsulfatase A. The crystal structure of human saposin B reveals an unusual shell-like dimer consisting of a monolayer of alpha-helices enclosing a large hydrophobic cavity. Although the secondary structure of saposin B is similar to that of the known monomeric members of the saposin-like superfamily, the helices are repacked into a different tertiary arrangement to form the homodimer. A comparison of the two forms of the saposin B dimer suggests that extraction of target lipids from membranes involves a conformational change that facilitates access to the inner cavity.
+The line below this paragraph, {{ABSTRACT_PUBMED_12518053}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12518053 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12518053}}
 ==About this Structure==
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 [[Category: Glycosphingolipid activator protein]]
 [[Category: Lipid binding protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:08:52 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:45:16 2008''