1n5u: Difference between revisions

Revision as of 12:34, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1n5u.png

Template:STRUCTURE 1n5u

X-RAY STUDY OF HUMAN SERUM ALBUMIN COMPLEXED WITH HEMEX-RAY STUDY OF HUMAN SERUM ALBUMIN COMPLEXED WITH HEME

Template:ABSTRACT PUBMED 11866438

About this StructureAbout this Structure

1N5U is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The atomic structure of human methemalbumin at 1.9 A., Wardell M, Wang Z, Ho JX, Robert J, Ruker F, Ruble J, Carter DC, Biochem Biophys Res Commun. 2002 Mar 8;291(4):813-9. PMID:11866438

Page seeded by OCA on Mon Jul 28 12:34:53 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''X-RAY STUDY OF HUMAN SERUM ALBUMIN COMPLEXED WITH HEME'''
+===X-RAY STUDY OF HUMAN SERUM ALBUMIN COMPLEXED WITH HEME===
-==Overview==
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-The high resolution structure of hemalbumin was determined by single crystal X-ray diffraction to a resolution of 1.9 A. The structure revealed the protoporphyrin IX bound to a single site within a hydrophobic cavity in subdomain IB, one of the principal binding sites for long chain fatty acid. The iron is penta coordinated with the fifth ligand comprised of the hydroxyl oxygen of Tyr-161 (phenolic oxygen to heme plane distance: 2.73 A) in an otherwise completely hydrophobic pocket. The heme propionic acid residues form salt bridges with His-142 and Lys-190, which together with a series of hydrophobic interactions, enclose and secure the heme within the IB helical motif. A detailed discussion of the structure together with its implications for the development of potential blood substitutes is presented.
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+{{ABSTRACT_PUBMED_11866438}}
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 [[Category: Wardell, M.]]
 [[Category: Plasma protein]]
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