1muk: Difference between revisions

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OCA

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-[[Image:1muk.gif|left|200px]]
+{{Seed}}
+[[Image:1muk.png|left|200px]]
 <!--
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 {{STRUCTURE_1muk|  PDB=1muk  |  SCENE=  }}
-'''reovirus lambda3 native structure'''
+===reovirus lambda3 native structure===
-==Overview==
+<!--
-The reovirus polymerase and those of other dsRNA viruses function within the confines of a protein capsid to transcribe the tightly packed dsRNA genome segments. The crystal structure of the reovirus polymerase, lambda3, determined at 2.5 A resolution, shows a fingers-palm-thumb core, similar to those of other viral polymerases, surrounded by major N- and C-terminal elaborations, which create a cage-like structure, with four channels leading to the catalytic site. This "caged" polymerase has allowed us to visualize the results of several rounds of RNA polymerization directly in the crystals. A 5' cap binding site on the surface of lambda3 suggests a template retention mechanism by which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the minus-sense strand into the template channel.
+The line below this paragraph, {{ABSTRACT_PUBMED_12464184}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12464184 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12464184}}
 ==About this Structure==
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 [[Category: Single subunit polymerase fold]]
 [[Category: Thumb]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:44:21 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:39:59 2008''