2mfn: Difference between revisions
New page: left|200px<br /> <applet load="2mfn" size="450" color="white" frame="true" align="right" spinBox="true" caption="2mfn" /> '''SOLUTION NMR STRUCTURE OF LINKED CELL ATTAC... |
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==About this Structure== | ==About this Structure== | ||
2MFN is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2MFN OCA]]. | 2MFN is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]]. Structure known Active Sites: RGD and SGY. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2MFN OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: rgd]] | [[Category: rgd]] | ||
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Revision as of 12:40, 30 October 2007
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SOLUTION NMR STRUCTURE OF LINKED CELL ATTACHMENT MODULES OF MOUSE FIBRONECTIN CONTAINING THE RGD AND SYNERGY REGIONS, 10 STRUCTURES
OverviewOverview
We report the three-dimensional solution structure of the mouse, fibronectin cell attachment domain consisting of the linked ninth and, tenth type III modules, mFnFn3(9,10). Because the tenth module contains, the RGD cell attachment sequence while the ninth contains the synergy, region, mFnFn3(9,10) has the cell attachment activity of intact, fibronectin. Essentially complete signal assignments and approximately, 1800 distance and angle restraints were derived from multidimensional, heteronuclear NMR spectra. These restraints were used with a hybrid, distance geometry/simulated annealing protocol to generate an ensemble of, 20 NMR structures having no distance or angle violations greater than 0.3, A or 3 degrees. Although the beta-sheet core domains of the individual, modules are ... [(full description)]
About this StructureAbout this Structure
2MFN is a [Single protein] structure of sequence from [Mus musculus]. Structure known Active Sites: RGD and SGY. Full crystallographic information is available from [OCA].
ReferenceReference
Solution structure and dynamics of linked cell attachment modules of mouse fibronectin containing the RGD and synergy regions: comparison with the human fibronectin crystal structure., Copie V, Tomita Y, Akiyama SK, Aota S, Yamada KM, Venable RM, Pastor RW, Krueger S, Torchia DA, J Mol Biol. 1998 Apr 3;277(3):663-82. PMID:9533887
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