1miz: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1miz.gif|left|200px]]
+{{Seed}}
+[[Image:1miz.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1miz|  PDB=1miz  |  SCENE=  }}
-'''Crystal structure of an integrin beta3-talin chimera'''
+===Crystal structure of an integrin beta3-talin chimera===
-==Overview==
+<!--
-The binding of cytoplasmic proteins, such as talin, to the cytoplasmic domains of integrin adhesion receptors mediates bidirectional signal transduction. Here we report the crystal structure of the principal integrin binding and activating fragment of talin, alone and in complex with fragments of the beta 3 integrin tail. The FERM (four point one, ezrin, radixin, and moesin) domain of talin engages integrins via a novel variant of the canonical phosphotyrosine binding (PTB) domain-NPxY ligand interaction that may be a prototype for FERM domain recognition of transmembrane receptors. In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the integrin beta 3 tail, providing structural paradigms for integrin linkage to the cell interior.
+The line below this paragraph, {{ABSTRACT_PUBMED_12535520}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12535520 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12535520}}
 ==About this Structure==
@@ Line 36: / Line 40: @@
 [[Category: Npxy motif]]
 [[Category: Ptb domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:08:52 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 00:04:39 2008''