1fgb: Difference between revisions
New page: left|200px<br /> <applet load="1fgb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fgb, resolution 2.4Å" /> '''TOXIN'''<br /> ==Ov... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
1FGB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FGB OCA]]. | 1FGB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]]. Structure known Active Site: GAN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FGB OCA]]. | ||
==Reference== | ==Reference== | ||
| Line 21: | Line 21: | ||
[[Category: enterotoxin]] | [[Category: enterotoxin]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:45:15 2007'' | ||
Revision as of 12:40, 30 October 2007
|
TOXIN
OverviewOverview
Cholera toxin, a heterohexameric AB5 enterotoxin released by Vibrio, cholera, induces a profuse secretory diarrhea in susceptible hosts., Choleragenoid, the B subunit pentamer of cholera toxin, directs the, enzymatic A subunit to its target by binding the GM1 gangliosides exposed, on the luminal surface of intestinal epithelial cells. The crystal, structure of choleragenoid has been independently solved and refined at, 2.4 A resolution by combining single isomorphous replacement with, non-crystallographic symmetry averaging. The structure of the B subunits, and their pentameric arrangement, closely resembles that reported for the, intact holotoxin, choleragen, the heat-labile enterotoxin from Escherichia, coli, and for a choleragenoid-GM1 pentasaccharide complex. In the absence, of the A ... [(full description)]
About this StructureAbout this Structure
1FGB is a [Single protein] structure of sequence from [Vibrio cholerae]. Structure known Active Site: GAN. Full crystallographic information is available from [OCA].
ReferenceReference
The 2.4 A crystal structure of cholera toxin B subunit pentamer: choleragenoid., Zhang RG, Westbrook ML, Westbrook EM, Scott DL, Otwinowski Z, Maulik PR, Reed RA, Shipley GG, J Mol Biol. 1995 Aug 25;251(4):550-62. PMID:7658472
Page seeded by OCA on Tue Oct 30 11:45:15 2007