1m1e: Difference between revisions

Revision as of 23:00, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1m1e.png

Template:STRUCTURE 1m1e

Beta-catenin armadillo repeat domain bound to ICATBeta-catenin armadillo repeat domain bound to ICAT

Template:ABSTRACT PUBMED 12408825

About this StructureAbout this Structure

1M1E is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules., Daniels DL, Weis WI, Mol Cell. 2002 Sep;10(3):573-84. PMID:12408825

Page seeded by OCA on Wed Jul 2 23:00:37 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1m1e.gif|left|200px]]
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-'''Beta-catenin armadillo repeat domain bound to ICAT'''
+===Beta-catenin armadillo repeat domain bound to ICAT===
-==Overview==
+<!--
-In the canonical Wnt signaling pathway, beta-catenin activates target genes through its interactions with Tcf/Lef-family transcription factors and additional transcriptional coactivators. The crystal structure of ICAT, an inhibitor of beta-catenin-mediated transcription, bound to the armadillo repeat domain of beta-catenin, has been determined. ICAT contains an N-terminal helilical domain that binds to repeats 11 and 12 of beta-catenin, and an extended C-terminal region that binds to repeats 5-10 in a manner similar to that of Tcfs and other beta-catenin ligands. Full-length ICAT dissociates complexes of beta-catenin, Lef-1, and the transcriptional coactivator p300, whereas the helical domain alone selectively blocks binding to p300. The C-terminal armadillo repeats of beta-catenin may be an attractive target for compounds designed to disrupt aberrant beta-catenin-mediated transcription associated with various cancers.
+The line below this paragraph, {{ABSTRACT_PUBMED_12408825}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12408825 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12408825}}
 ==About this Structure==
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 [[Category: Cytoskeleton]]
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-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:30:56 2008''
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