1m19: Difference between revisions

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-[[Image:1m19.gif|left|200px]]
+{{Seed}}
+[[Image:1m19.png|left|200px]]
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 {{STRUCTURE_1m19|  PDB=1m19  |  SCENE=  }}
-'''LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA'''
+===LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA===
-==Overview==
+<!--
-We determined the crystal structures of three nucleosome core particles in complex with site-specific DNA-binding ligands, the pyrrole-imidazole polyamides. While the structure of the histone octamer and its interaction with the DNA remain unaffected by ligand binding, nucleosomal DNA undergoes significant structural changes at the ligand-binding sites and in adjacent regions to accommodate the ligands. Our findings suggest that twist diffusion occurs over long distances through tightly bound nucleosomal DNA. This may be relevant to the mechanism of ATP-dependent and spontaneous nucleosome translocation, and to the effect of bound factors on nucleosome dynamics.
+The line below this paragraph, {{ABSTRACT_PUBMED_12559907}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12559907 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12559907}}
 ==About this Structure==
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 [[Category: Nucleosome]]
 [[Category: Pyrrole-imidazole polyamide]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:30:34 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 22:59:52 2008''