1lwc: Difference between revisions

Revision as of 22:39, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1lwc.png

Template:STRUCTURE 1lwc

CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINECRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE

Template:ABSTRACT PUBMED 12208978

About this StructureAbout this Structure

1LWC is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215., Chamberlain PP, Ren J, Nichols CE, Douglas L, Lennerstrand J, Larder BA, Stuart DI, Stammers DK, J Virol. 2002 Oct;76(19):10015-9. PMID:12208978

Page seeded by OCA on Wed Jul 2 22:38:55 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1lwc.jpg|left|200px]]
+{{Seed}}
+[[Image:1lwc.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1lwc|  PDB=1lwc  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE'''
+===CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE===
-==Overview==
+<!--
-Six structures of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) containing combinations of resistance mutations for zidovudine (AZT) (M41L and T215Y) or lamivudine (M184V) have been determined as inhibitor complexes. Minimal conformational changes in the polymerase or nonnucleoside RT inhibitor sites compared to the mutant RTMC (D67N, K70R, T215F, and K219N) are observed, indicating that such changes may occur only with certain combinations of mutations. Model building M41L and T215Y into HIV-1 RT-DNA and docking in ATP that is utilized in the pyrophosphorolysis reaction for AZT resistance indicates that some conformational rearrangement appears necessary in RT for ATP to interact simultaneously with the M41L and T215Y mutations.
+The line below this paragraph, {{ABSTRACT_PUBMED_12208978}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12208978 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12208978}}
 ==About this Structure==
@@ Line 36: / Line 40: @@
 [[Category: Nevirapine]]
 [[Category: Nrti]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:21:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 22:38:55 2008''