1oet: Difference between revisions
New page: left|200px<br /> <applet load="1oet" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oet, resolution 2.30Å" /> '''OXIDATION STATE OF ... |
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==About this Structure== | ==About this Structure== | ||
1OET is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OET OCA]]. | 1OET is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OET OCA]]. | ||
==Reference== | ==Reference== | ||
Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B., van Montfort RL, Congreve M, Tisi D, Carr R, Jhoti H, Nature. 2003 Jun 12;423(6941):773-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12802339 12802339] | Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B., van Montfort RL, Congreve M, Tisi D, Carr R, Jhoti H, Nature. 2003 Jun 12;423(6941):773-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12802339 12802339] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein-tyrosine-phosphatase]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Carr, R.]] | [[Category: Carr, R.]] | ||
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[[Category: protein tyrosine phosphatase]] | [[Category: protein tyrosine phosphatase]] | ||
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Revision as of 12:39, 30 October 2007
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OXIDATION STATE OF PROTEIN TYROSINE PHOSPHATASE 1B
OverviewOverview
Protein tyrosine phosphatases regulate signal transduction pathways, involving tyrosine phosphorylation and have been implicated in the, development of cancer, diabetes, rheumatoid arthritis and hypertension., Increasing evidence suggests that the cellular redox state is involved in, regulating tyrosine phosphatase activity through the reversible, oxidization of the catalytic cysteine to sulphenic acid (Cys-SOH). But how, further oxidation to the irreversible sulphinic (Cys-SO2H) and sulphonic, (Cys-SO3H) forms is prevented remains unclear. Here we report the crystal, structures of the regulatory sulphenic and irreversible sulphinic and, sulphonic acids of protein tyrosine phosphatase 1B (PTP1B), an important, enzyme in the negative regulation of the insulin receptor and a, therapeutic ... [(full description)]
About this StructureAbout this Structure
1OET is a [Single protein] structure of sequence from [Homo sapiens] with MG as [ligand]. Active as [Protein-tyrosine-phosphatase], with EC number [3.1.3.48]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B., van Montfort RL, Congreve M, Tisi D, Carr R, Jhoti H, Nature. 2003 Jun 12;423(6941):773-7. PMID:12802339
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