8cg9: Difference between revisions

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-'''Unreleased structure'''
-The entry 8cg9 is ON HOLD  until Paper Publication
+==Crystal structure of human DNA cross-link repair 1A in complex with a cyclic N-hydroxyurea inhibitor==
+<StructureSection load='8cg9' size='340' side='right'caption='[[8cg9]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
-Authors: Newman, J.A., Yosaatmadja, Y., Baddock, H.T., Bielinski, M., von Delft, F., Bountra, C., McHugh, P.J., Schofield, C.J., Gileadi, O.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8cg9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CG9 FirstGlance]. <br>
-Description: Crystal structure of human DNA cross-link repair 1A in complex with a cyclic N-hydroxyurea inhibitor
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=R3Z:1-[(2S)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYL]-3-HYDROXYTHIENO[3,2-D]PYRIMIDINE-2,4(1H,3H)-DIONE'>R3Z</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XOB:1-[[(3~{R})-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-3-oxidanyl-thieno[3,2-d]pyrimidine-2,4-dione'>XOB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Yosaatmadja, Y]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cg9 OCA], [https://pdbe.org/8cg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cg9 RCSB], [https://www.ebi.ac.uk/pdbsum/8cg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cg9 ProSAT]</span></td></tr>
-[[Category: Bielinski, M]]
+</table>
-[[Category: Von Delft, F]]
+== Function ==
-[[Category: Baddock, H.T]]
+[https://www.uniprot.org/uniprot/DCR1A_HUMAN DCR1A_HUMAN] May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.<ref>PMID:15542852</ref>
-[[Category: Gileadi, O]]
+== References ==
-[[Category: Newman, J.A]]
+<references/>
-[[Category: Mchugh, P.J]]
+__TOC__
-[[Category: Bountra, C]]
+</StructureSection>
-[[Category: Schofield, C.J]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Baddock HT]]
+[[Category: Bielinski M]]
+[[Category: Bountra C]]
+[[Category: Gileadi O]]
+[[Category: McHugh PJ]]
+[[Category: Newman JA]]
+[[Category: Schofield CJ]]
+[[Category: Yosaatmadja Y]]
+[[Category: Von Delft F]]