1lgl: Difference between revisions

Revision as of 20:52, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1lgl.png

Template:STRUCTURE 1lgl

Solution structure of HERG-specific scorpion toxin BeKm-1Solution structure of HERG-specific scorpion toxin BeKm-1

Template:ABSTRACT PUBMED 12151390

About this StructureAbout this Structure

1LGL is a Single protein structure of sequence from Mesobuthus eupeus. Full experimental information is available from OCA.

ReferenceReference

New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1., Korolkova YV, Bocharov EV, Angelo K, Maslennikov IV, Grinenko OV, Lipkin AV, Nosyreva ED, Pluzhnikov KA, Olesen SP, Arseniev AS, Grishin EV, J Biol Chem. 2002 Nov 8;277(45):43104-9. Epub 2002 Jul 31. PMID:12151390

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OCA

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-[[Image:1lgl.gif|left|200px]]
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-'''Solution structure of HERG-specific scorpion toxin BeKm-1'''
+===Solution structure of HERG-specific scorpion toxin BeKm-1===
-==Overview==
+<!--
-The scorpion toxin BeKm-1 is unique among a variety of known short scorpion toxins affecting potassium channels in its selective action on ether-a-go-go-related gene (ERG)-type channels. BeKm-1 shares the common molecular scaffold with other short scorpion toxins. The toxin spatial structure resolved by NMR consists of a short alpha-helix and a triple-stranded antiparallel beta-sheet. By toxin mutagenesis study we identified the residues that are important for the binding of BeKm-1 to the human ERG K+ (HERG) channel. The most critical residues (Tyr-11, Lys-18, Arg-20, Lys-23) are located in the alpha-helix and following loop whereas the "traditional" functional site of other short scorpion toxins is formed by residues from the beta-sheet. Thus the unique location of the binding site of BeKm-1 provides its specificity toward the HERG channel.
+The line below this paragraph, {{ABSTRACT_PUBMED_12151390}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12151390 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12151390}}
 ==About this Structure==
-LGL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesobuthus_eupeus Mesobuthus eupeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LGL OCA].
+LGL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesobuthus_eupeus Mesobuthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LGL OCA].
 ==Reference==
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 [[Category: Alpha-beta motif]]
 [[Category: Cysteine-knot motif]]
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