1l7c: Difference between revisions

Revision as of 11:51, 2 July 2008

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File:1l7c.png

Template:STRUCTURE 1l7c

alpha-catenin fragment, residues 385-651alpha-catenin fragment, residues 385-651

Template:ABSTRACT PUBMED 11907041

About this StructureAbout this Structure

1L7C is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin., Pokutta S, Drees F, Takai Y, Nelson WJ, Weis WI, J Biol Chem. 2002 May 24;277(21):18868-74. Epub 2002 Mar 20. PMID:11907041

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OCA

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-'''alpha-catenin fragment, residues 385-651'''
+===alpha-catenin fragment, residues 385-651===
-==Overview==
+<!--
-alpha-Catenin is an integral component of adherens junctions, where it links cadherins to the actin cytoskeleton. alpha-Catenin is also required for the colocalization of the nectin/afadin/ponsin adhesion system to adherens junctions, and it specifically associates with the nectin-binding protein afadin. A proteolytic fragment of alpha-catenin, residues 385-651, contains the afadin-binding site. The three-dimensional structure of this fragment comprises two side-by-side four-helix bundles, both of which are required for afadin binding. The alpha-catenin fragment 385-651 binds afadin more strongly than the full-length protein, suggesting that the full-length protein harbors a cryptic binding site for afadin. Comparison of the alpha-catenin 385-651 structure with the recently solved structure of the alpha-catenin M-fragment (Yang, J., Dokurno, P., Tonks, N. K., and Barford, D. (2001) EMBO J. 20, 3645-3656) reveals a surprising flexibility in the orientation of the two four-helix bundles. alpha-Catenin and the actin-binding protein vinculin share sequence and most likely structural similarity within their actin-binding domains. Despite this homology, actin binding requires additional sequences adjacent to this region.
+The line below this paragraph, {{ABSTRACT_PUBMED_11907041}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_11907041}}
 ==About this Structure==
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 [[Category: Weis, W I.]]
 [[Category: Four-helix bundle]]
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