4a1m: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4a1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A1M FirstGlance]. <br>
<table><tr><td colspan='2'>[[4a1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A1M FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a1m OCA], [https://pdbe.org/4a1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a1m RCSB], [https://www.ebi.ac.uk/pdbsum/4a1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a1m ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a1m OCA], [https://pdbe.org/4a1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a1m RCSB], [https://www.ebi.ac.uk/pdbsum/4a1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a1m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==

Latest revision as of 09:00, 19 June 2024

NMR Structure of protoporphyrin-IX bound murine p22HBPNMR Structure of protoporphyrin-IX bound murine p22HBP

Structural highlights

4a1m is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HEBP1_MOUSE May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.[1] [2]

References

  1. ↑ Jacob Blackmon B, Dailey TA, Lianchun X, Dailey HA. Characterization of a human and mouse tetrapyrrole-binding protein. Arch Biochem Biophys. 2002 Nov 15;407(2):196-201. PMID:12413491
  2. ↑ Dias JS, Macedo AL, Ferreira GC, Peterson FC, Volkman BF, Goodfellow BJ. The first structure from the SOUL/HBP family of heme-binding proteins, murine P22HBP. J Biol Chem. 2006 Oct 20;281(42):31553-61. Epub 2006 Aug 10. PMID:16905545 doi:10.1074/jbc.M605988200
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