8jaa: Difference between revisions

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'''Unreleased structure'''


The entry 8jaa is ON HOLD  until Paper Publication
==Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-04==
 
<StructureSection load='8jaa' size='340' side='right'caption='[[8jaa]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
Authors: Zhang, B., Liang, J., Rao, Z.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8jaa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JAA FirstGlance]. <br>
Description: Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-04
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TY6:(2~{S},3~{R},4~{S},5~{S},6~{S})-6-[(2-azanylhydrazinyl)methyl]oxane-2,3,4,5-tetrol'>TY6</scene></td></tr>
[[Category: Zhang, B]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jaa OCA], [https://pdbe.org/8jaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jaa RCSB], [https://www.ebi.ac.uk/pdbsum/8jaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jaa ProSAT]</span></td></tr>
[[Category: Liang, J]]
</table>
[[Category: Rao, Z]]
== Function ==
[https://www.uniprot.org/uniprot/LPQY_MYCTU LPQY_MYCTU] Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence.<ref>PMID:21118978</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Liang J]]
[[Category: Rao Z]]
[[Category: Zhang B]]

Revision as of 15:35, 4 October 2023

Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-04Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-04

Structural highlights

8jaa is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LPQY_MYCTU Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence.[1]

References

  1. ↑ Kalscheuer R, Weinrick B, Veeraraghavan U, Besra GS, Jacobs WR Jr. Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21761-6. doi:, 10.1073/pnas.1014642108. Epub 2010 Nov 30. PMID:21118978 doi:http://dx.doi.org/10.1073/pnas.1014642108

8jaa, resolution 1.70Å

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