8ja8: Difference between revisions

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'''Unreleased structure'''


The entry 8ja8 is ON HOLD  until Paper Publication
==Crystal structure of Mycobacterium tuberculosis LpqY with trehalose bound in a closed liganded form==
 
<StructureSection load='8ja8' size='340' side='right'caption='[[8ja8]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
Authors: Zhang, B., Liang, J., Rao, Z.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8ja8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JA8 FirstGlance]. <br>
Description: Crystal structure of Mycobacterium tuberculosis LpqY with trehalose bound in a closed liganded form
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Zhang, B]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ja8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ja8 OCA], [https://pdbe.org/8ja8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ja8 RCSB], [https://www.ebi.ac.uk/pdbsum/8ja8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ja8 ProSAT]</span></td></tr>
[[Category: Liang, J]]
</table>
[[Category: Rao, Z]]
== Function ==
[https://www.uniprot.org/uniprot/LPQY_MYCTU LPQY_MYCTU] Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence.<ref>PMID:21118978</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Liang J]]
[[Category: Rao Z]]
[[Category: Zhang B]]

Revision as of 09:59, 27 September 2023

Crystal structure of Mycobacterium tuberculosis LpqY with trehalose bound in a closed liganded formCrystal structure of Mycobacterium tuberculosis LpqY with trehalose bound in a closed liganded form

Structural highlights

8ja8 is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LPQY_MYCTU Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence.[1]

References

  1. ↑ Kalscheuer R, Weinrick B, Veeraraghavan U, Besra GS, Jacobs WR Jr. Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21761-6. doi:, 10.1073/pnas.1014642108. Epub 2010 Nov 30. PMID:21118978 doi:http://dx.doi.org/10.1073/pnas.1014642108

8ja8, resolution 1.60Å

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OCA
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