2v3t: Difference between revisions
New page: left|200px<br /> <applet load="2v3t" size="450" color="white" frame="true" align="right" spinBox="true" caption="2v3t, resolution 2.75Å" /> '''STRUCTURE OF THE LI... |
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==About this Structure== | ==About this Structure== | ||
2V3T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V3T OCA]]. | 2V3T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V3T OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: transport]] | [[Category: transport]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:42:59 2007'' | ||
Revision as of 12:38, 30 October 2007
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STRUCTURE OF THE LIGAND-BINDING CORE OF THE IONOTROPIC GLUTAMATE RECEPTOR-LIKE GLURDELTA2 IN THE APO FORM
OverviewOverview
The orphan glutamate-like receptor GluRdelta2 is predominantly expressed, in Purkinje cells of the central nervous system. The classification of, GluRdelta2 to the ionotropic glutamate receptor family is based on, sequence similarities, because GluRdelta2 does not form functional, homomeric glutamate-gated ion channels in transfected cells. Studies in, GluRdelta2(-/-) knockout mice as well as in mice with naturally occurring, mutations in the GluRdelta2 gene have demonstrated an essential role of, GluRdelta2 in cerebellar long-term depression, motor learning, motor, coordination, and synaptogenesis. However, the lack of a known agonist has, hampered investigations on the function of GluRdelta2. In this study, the, ligand-binding core of GluRdelta2 (GluRdelta2-S1S2) was found to bind, ... [(full description)]
About this StructureAbout this Structure
2V3T is a [Single protein] structure of sequence from [Rattus norvegicus] with CA as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Ionotropic glutamate-like receptor {delta}2 binds D-serine and glycine., Naur P, Hansen KB, Kristensen AS, Dravid SM, Pickering DS, Olsen L, Vestergaard B, Egebjerg J, Gajhede M, Traynelis SF, Kastrup JS, Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14116-21. Epub 2007 Aug 21. PMID:17715062
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