7ynk: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7ynk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YNK FirstGlance]. <br> | <table><tr><td colspan='2'>[[7ynk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YNK FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ynk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ynk OCA], [https://pdbe.org/7ynk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ynk RCSB], [https://www.ebi.ac.uk/pdbsum/7ynk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ynk ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.48Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ynk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ynk OCA], [https://pdbe.org/7ynk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ynk RCSB], [https://www.ebi.ac.uk/pdbsum/7ynk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ynk ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
Revision as of 19:10, 13 December 2023
Structure of human SGLT2-MAP17 complex in the apo state in the inward-facing conformationStructure of human SGLT2-MAP17 complex in the apo state in the inward-facing conformation
Structural highlights
DiseaseSC5A2_HUMAN Familial renal glucosuria. The disease is caused by variants affecting the gene represented in this entry. FunctionSC5A2_HUMAN Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).[UniProtKB:Q923I7][1] [2] [3] References
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