1kpf: Difference between revisions

Revision as of 10:42, 2 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1kpf.png

Template:STRUCTURE 1kpf

PKCI-SUBSTRATE ANALOGPKCI-SUBSTRATE ANALOG

Template:ABSTRACT PUBMED 9323207

About this StructureAbout this Structure

1KPF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure-based analysis of catalysis and substrate definition in the HIT protein family., Lima CD, Klein MG, Hendrickson WA, Science. 1997 Oct 10;278(5336):286-90. PMID:9323207

Page seeded by OCA on Wed Jul 2 10:42:43 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''PKCI-SUBSTRATE ANALOG'''
+===PKCI-SUBSTRATE ANALOG===
-==Overview==
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-The histidine triad (HIT) protein family is among the most ubiquitous and highly conserved in nature, but a biological activity has not yet been identified for any member of the HIT family. Fragile histidine triad protein (FHIT) and protein kinase C interacting protein (PKCI) were used in a structure-based approach to elucidate characteristics of in vivo ligands and reactions. Crystallographic structures of apo, substrate analog, pentacovalent transition-state analog, and product states of both enzymes reveal a catalytic mechanism and define substrate characteristics required for catalysis, thus unifying the HIT family as nucleotidyl hydrolases, transferases, or both. The approach described here may be useful in identifying structure-function relations between protein families identified through genomics.
+The line below this paragraph, {{ABSTRACT_PUBMED_9323207}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_9323207}}
 ==About this Structure==
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 [[Category: Pkci-1]]
 [[Category: Protein kinase inhibitor]]
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