Sandbox Reserved 1767: Difference between revisions

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Revision as of 19:43, 17 April 2023 view source Sloan August (talk \| contribs) 180 edits No edit summary ← Older edit		Revision as of 19:44, 17 April 2023 view source Sloan August (talk \| contribs) 180 edits No edit summary Newer edit →
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	MRAS contains two regions called Switch I (SWI) and Switch II (SWII) that undergo conformational changes depending if MRAS is bound to GDP or GTP <ref name="Liau">PMID: 35768504</ref>. The conformation of these switches determines if the SMP complex can form or not. Mutations to MRAS can lead to consistent GTP-loading, causing an increase in the formation of the SMP complex ~~and there is~~ consistent activation of the cell-proliferation pathway in the absence of external growth factors.		MRAS contains two regions called Switch I (SWI) and Switch II (SWII) that undergo conformational changes depending if MRAS is bound to GDP or GTP <ref name="Liau">PMID: 35768504</ref>. The conformation of these switches determines if the SMP complex can form or not. Mutations to MRAS can lead to consistent GTP-loading, causing an increase in the formation of the SMP complex as well as consistent activation of the cell-proliferation pathway in the absence of external growth factors.