1k6y: Difference between revisions

Revision as of 09:52, 2 July 2008

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File:1k6y.png

Template:STRUCTURE 1k6y

Crystal Structure of a Two-Domain Fragment of HIV-1 IntegraseCrystal Structure of a Two-Domain Fragment of HIV-1 Integrase

Template:ABSTRACT PUBMED 11743009

About this StructureAbout this Structure

1K6Y is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

ReferenceReference

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein., Wang JY, Ling H, Yang W, Craigie R, EMBO J. 2001 Dec 17;20(24):7333-43. PMID:11743009

Page seeded by OCA on Wed Jul 2 09:52:44 2008

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OCA

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-'''Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase'''
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-==Overview==
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-Retroviral integrase, an essential enzyme for replication of human immunodeficiency virus type-1 (HIV-1) and other retroviruses, contains three structurally distinct domains, an N-terminal domain, the catalytic core and a C-terminal domain. To elucidate their spatial arrangement, we have solved the structure of a fragment of HIV-1 integrase comprising the N-terminal and catalytic core domains. This structure reveals a dimer interface between the N-terminal domains different from that observed for the isolated domain. It also complements the previously determined structure of the C-terminal two domains of HIV-1 integrase; superposition of the conserved catalytic core of the two structures results in a plausible full-length integrase dimer. Furthermore, an integrase tetramer formed by crystal lattice contacts bears structural resemblance to a related bacterial transposase, Tn5, and exhibits positively charged channels suitable for DNA binding.
+The line below this paragraph, {{ABSTRACT_PUBMED_11743009}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_11743009}}
 ==About this Structure==
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 [[Category: Hiv-1]]
 [[Category: Integrase]]
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