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| {{STRUCTURE_1k68| PDB=1k68 | SCENE= }} | | {{STRUCTURE_1k68| PDB=1k68 | SCENE= }} |
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| '''Crystal Structure of the Phosphorylated Cyanobacterial Phytochrome Response Regulator RcpA'''
| | ===Crystal Structure of the Phosphorylated Cyanobacterial Phytochrome Response Regulator RcpA=== |
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| ==Overview==
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| The structures of two response regulators (RRs) from the cyanobacterium Calothrix PCC7601, RcpA and RcpB, were solved to 1.9- and 1.75-A resolution, respectively. RcpA was found in phosphorylated and RcpB in nonphosphorylated form. Both RRs are members of phytochrome-associated, light-sensing two-component signal transduction pathways, based on histidine kinase-mediated receptor autophosphorylation and phosphorelay to a RR. Despite the overall folding similarity to CheY-type RRs ((beta/alpha)(5)-motif), RcpA and RcpB form homodimers, irrespective of their phosphorylation state, giving insight into a signal transduction putatively different from that of other known RRs. Dimerization is accomplished by a C-terminal extension of the RR polypeptide chain, and the surface formed by H4, beta 5, and H5, which constitute a hydrophobic contact area with distinct interactions between residues of either subunit. Sequence alignments reveal that the identified dimerization motif is archetypal for phytochrome-associated RRs, making them a novel subgroup of CheY-type RRs. The protein structures of RcpA and RcpB are compared to the recently presented protein structure of Rcp1 from Synechocystis. | | The line below this paragraph, {{ABSTRACT_PUBMED_15240481}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15240481 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15240481}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Phosphorylated aspartate]] | | [[Category: Phosphorylated aspartate]] |
| [[Category: Response regulator]] | | [[Category: Response regulator]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:21:29 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:50:46 2008'' |