8hsc: Difference between revisions

Revision as of 10:38, 8 March 2023

Gi bound Orphan GPR20 complex with Fab046 in ligand-free stateGi bound Orphan GPR20 complex with Fab046 in ligand-free state

Structural highlights

8hsc is a 7 chain structure with sequence from Escherichia coli, Homo sapiens, Rattus and Vicugna pacos. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GNAI1_HUMAN Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.^[1] ^[2]

References

↑ Cho H, Kehrl JH. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007 Jul 16;178(2):245-55. PMID:17635935 doi:10.1083/jcb.200604114
↑ Johnston CA, Siderovski DP. Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:17264214

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OCA

[1] Cho H, Kehrl JH. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007 Jul 16;178(2):245-55. PMID:17635935 doi:10.1083/jcb.200604114

[2] Johnston CA, Siderovski DP. Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:17264214

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8hsc is ON HOLD  until Paper Publication
+==Gi bound Orphan GPR20 complex with Fab046 in ligand-free state==
+<StructureSection load='8hsc' size='340' side='right'caption='[[8hsc]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
-Authors: Lin, X., Jiang, S., Xu, F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8hsc]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus Rattus] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HSC FirstGlance]. <br>
-Description: Gi bound Orphan GPR20 complex with Fab046 in ligand-free state
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hsc OCA], [https://pdbe.org/8hsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hsc RCSB], [https://www.ebi.ac.uk/pdbsum/8hsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hsc ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Xu, F]]
+== Function ==
-[[Category: Jiang, S]]
+[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
-[[Category: Lin, X]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Escherichia coli]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Rattus]]
+[[Category: Vicugna pacos]]
+[[Category: Jiang S]]
+[[Category: Lin X]]
+[[Category: Xu F]]

8hsc: Difference between revisions

Revision as of 10:38, 8 March 2023

Gi bound Orphan GPR20 complex with Fab046 in ligand-free stateGi bound Orphan GPR20 complex with Fab046 in ligand-free state

Structural highlights

Function

References

Contents

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8hsc: Difference between revisions

Revision as of 10:38, 8 March 2023

Gi bound Orphan GPR20 complex with Fab046 in ligand-free stateGi bound Orphan GPR20 complex with Fab046 in ligand-free state

Structural highlights

Function

References

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