1ido: Difference between revisions
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[[Image:1ido.gif|left|200px]]<br /> | [[Image:1ido.gif|left|200px]]<br /><applet load="1ido" size="450" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1ido" size="450" color="white" frame="true" align="right" spinBox="true" | |||
caption="1ido, resolution 1.7Å" /> | caption="1ido, resolution 1.7Å" /> | ||
'''I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND'''<br /> | '''I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1IDO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. | 1IDO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=MG:Metal Binding Site. This Site Also Includes GLU 314 From ...'>MG</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IDO OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: integrin]] | [[Category: integrin]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 16:33:29 2007'' | ||
Revision as of 17:23, 18 December 2007
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I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND
OverviewOverview
We have determined the high resolution crystal structure of the A domain, from the alpha chain of integrin CR3. The domain adopts a classic, alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site, at its surface. One of the coordinating ligands is the glutamate side, chain from another A domain molecule. We suggest that this site represents, a general metal ion-dependent adhesion site (MIDAS) for binding protein, ligands. We further propose that the beta subunits of integrins contain a, MIDAS motif within a modified A domain. Our crystal structure will allow, reliable models to be built for other members of the A domain superfamily, and should facilitate development of novel adhesion modulatory drugs.
About this StructureAbout this Structure
1IDO is a Single protein structure of sequence from Homo sapiens with MG as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:7867070
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