1jpa: Difference between revisions

Revision as of 20:35, 1 July 2008

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File:1jpa.png

Template:STRUCTURE 1jpa

Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane regionCrystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region

Template:ABSTRACT PUBMED 11572780

About this StructureAbout this Structure

1JPA is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region., Wybenga-Groot LE, Baskin B, Ong SH, Tong J, Pawson T, Sicheri F, Cell. 2001 Sep 21;106(6):745-57. PMID:11572780

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OCA

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-'''Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region'''
+===Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region===
-==Overview==
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-The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. We have solved the X-ray crystal structure to 1.9 A resolution of an autoinhibited, unphosphorylated form of EphB2 comprised of the juxtamembrane region and the kinase domain. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins. We propose that the autoinhibitory mechanism employed by EphB2 is a more general device through which receptor tyrosine kinases are controlled.
+The line below this paragraph, {{ABSTRACT_PUBMED_11572780}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_11572780}}
 ==About this Structure==
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 [[Category: Receptor tyrosine kinase]]
 [[Category: Unphosphorylated]]
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