4nqm: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4nqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NQM FirstGlance]. <br> | <table><tr><td colspan='2'>[[4nqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NQM FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=Y1Z:2-CHLORO-N-[5-(3-METHYL[1,2,4]TRIAZOLO[3,4-A]PHTHALAZIN-6-YL)-2-(MORPHOLIN-4-YL)PHENYL]BENZENESULFONAMIDE'>Y1Z</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=Y1Z:2-CHLORO-N-[5-(3-METHYL[1,2,4]TRIAZOLO[3,4-A]PHTHALAZIN-6-YL)-2-(MORPHOLIN-4-YL)PHENYL]BENZENESULFONAMIDE'>Y1Z</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nqm OCA], [https://pdbe.org/4nqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nqm RCSB], [https://www.ebi.ac.uk/pdbsum/4nqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nqm ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nqm OCA], [https://pdbe.org/4nqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nqm RCSB], [https://www.ebi.ac.uk/pdbsum/4nqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nqm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 15:34, 1 March 2024
Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligandCrystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand
Structural highlights
DiseaseBRD4_HUMAN Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2] FunctionBRD4_HUMAN Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). See AlsoReferences
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