8fe5: Difference between revisions

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'''Unreleased structure'''


The entry 8fe5 is ON HOLD  until Paper Publication
==Structure of J-PKAc chimera complexed with Aplithianine B==
 
<StructureSection load='8fe5' size='340' side='right'caption='[[8fe5]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
Authors: Du, L., Wilson, B.A.P., Li, N., Martinez Fiesco, J.A., Dalilian, M., Wang, D., Smith, E.A., Wamiru, A., Goncharova, E.I., Zhang, P., O''Keefe, B.R.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8fe5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FE5 FirstGlance]. <br>
Description: Structure of J-PKAc chimera complexed with Aplithianine B
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=XTT:6-[(6P)-6-(1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-7,9-dihydro-8H-purin-8-one'>XTT</scene></td></tr>
[[Category: Martinez Fiesco, J.A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fe5 OCA], [https://pdbe.org/8fe5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fe5 RCSB], [https://www.ebi.ac.uk/pdbsum/8fe5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fe5 ProSAT]</span></td></tr>
[[Category: Zhang, P]]
</table>
[[Category: Wang, D]]
== Function ==
[[Category: Dalilian, M]]
[https://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
[[Category: Goncharova, E.I]]
__TOC__
[[Category: Wamiru, A]]
</StructureSection>
[[Category: Wilson, B.A.P]]
[[Category: Homo sapiens]]
[[Category: Du, L]]
[[Category: Large Structures]]
[[Category: O''Keefe, B.R]]
[[Category: Dalilian M]]
[[Category: Li, N]]
[[Category: Du L]]
[[Category: Smith, E.A]]
[[Category: Goncharova EI]]
[[Category: Li N]]
[[Category: Martinez Fiesco JA]]
[[Category: O'Keefe BR]]
[[Category: Smith EA]]
[[Category: Wamiru A]]
[[Category: Wang D]]
[[Category: Wilson BAP]]
[[Category: Zhang P]]

Revision as of 17:05, 18 October 2023

Structure of J-PKAc chimera complexed with Aplithianine BStructure of J-PKAc chimera complexed with Aplithianine B

Structural highlights

8fe5 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.51Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IPKA_HUMAN Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

8fe5, resolution 2.51Å

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OCA
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