Polycomb proteins: Difference between revisions

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== Structural highlights ==
== Structural highlights ==


</StructureSection>
</StructureSection>


==3D structures of polycomb complex proteins==
==3D structures of polycomb proteins==
 
[[Polycomb complex protein 3D structures]]
[[Polycomb complex proteins 3D structures]]
 
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Polycomb BMI1
 
**[[5fr6]] - hPcG -  human<br />
**[[3rpg]] - hPcG + RING1B + Ubch5C<br />
**[[4r8p]] - hPcG + RING1B + Ubch5C + histones + DNA<br />
 
*Polycomb EED
 
**[[5wf7]], [[5bjs]], [[5vk3]] - CtPcG + EZH2/PcG SUZ12 -  ''Chaetomium thermophilum''<br />
**[[5wfd]] - CtPcG + zinc finger containing protein + inhibitor<br />
**[[5wfc]] - CtPcG (mutant) + EZH2/PcG SUZ12 + histone peptide + inhibitor<br />
**[[5tqr]] - CtPcGCP + EZH2/PCP SUZ12 + SAM<br />
**[[3jzn]] - hPcG  <br />
**[[5wg6]] - hPcG + EZH2 <br />
**[[5ij7]], [[5ij8]], [[4w2r]], [[6b3w]] - hPcG + EZH2 + PcG SUZ12  + inhibitor<br />
**[[5ij8]] - hPcG + EZH2 + PcG SUZ12  + inhibitor<br />
**[[5ls6]] - hPcG + EZH2 + PcG SUZ12 + Jarid2 K116me3 <br />
**[[5hyn]] - hPcG + EZH2 + PcG SUZ12 + Jarid2 K116me3 + histone peptide<br />
**[[6c23]], [[6c24]] - hPcG + EZH2 + PcG SUZ12 + Jarid2 substrate + Jumonji + SUZ12 + RBBP4 - Cryo EM<br />
**[[4x3e]] - hPcG + Jarid2 peptide <br />
**[[3jpx]], [[3iiw]], [[3iiy]], [[3ij0]], [[3ij1]], [[3jzg]], [[3jzh]], [[3k26]],[[5fr6]] - hPcG <br />
**[[5u69]], [[5u6d]], [[5u8a]], [[5k0m]], [[5h13]], [[5u5h]], [[5u5k]], [[5u8f]] - hPcG + inhibitor <br />
**[[3ijc]] - hPcG (mutant) + inhibitor <br />
**[[5wp3]] - hPcG + EB22 <br />
**[[5ttw]] - hPcG + UNC4859 <br />
**[[5h14]], [[5h15]], [[5h17]], [[5h19]], [[5u5t]], [[5u62]], [[5h25]], [[5gsa]], [[5h24]], [[5wuk]] - hPcG + EZH2 + inhibitor <br />
**[[1pdq]], [[1pfb]] - DmPcG chromodomain + histone peptide - ''Drosophila melanogaster''<br />
 
*Polycomb SUZ12
 
**[[5wak]] - hPcG + RBBP4 <br />
**[[5wai]] - hPcG + RBBP4 + Jarid2 + AEPB2 <br />
**[[2yb8]] - DmPcG + CAF1<br />
 
*Polycomb SCMH1
 
**[[2p0k]] - hPcG <br />
 
*Polycomb SFMBT
 
**[[4c5e]], [[4c5g]], [[4c5h]] - DmPcG + PcG PHO <br />
**[[5j8y]] - DmPcG + PcG SCM <br />
**[[3h6z]] - DmPcG + histone peptide <br />
 
*Polycomb PCL
 
**[[2xk0]] - DmPcG tudor domain - NMR <br />
**[[5oqd]] - DmPcG Phd2 and winged-helix domain  <br />
 
*Polycomb SCM
 
**[[2r57]] - DmPcG (mutant) <br />
**[[2r58]], [[2r5a]] - DmPcG (mutant) + methyl-lysine<br />
**[[2r5m]] - DmPcG (mutant) + peptide <br />


}}


== References ==
== References ==

Revision as of 11:44, 9 January 2023


Function

Polycomb group (PcG) proteins are determinants of gene silencing and epigenetic memory in higher eukaryotes. The PcG system consists of multimeric repressive protein complexes containing chromatin modifying activities which regulate transcription by modulating chromatin structures. The PcG proteins regulate pathways in cell differentiation, tissue regeneration and cancer cell growth[1]. For the B-cell-specific Molony leukemia virus Insertion site 1 (BMI1) see BMI1.

See also: Polycomb complex protein.

Disease

Misregulation of PcG protein levels often lead to either a block or unscheduled activation of developmental pathways. the consequences of this misregulation have been linked to the establishment of cancer stem cells which can produce tumors. Cancer stem cells are believed to persist within tumors and to elicit relapse and metastasis[2]

Structural highlights

Human polycomb complex protein BMI-1 (olive and dark red) complex with histones (grey, green, yellow, pink, magenta, cyan, gold, red), RING1B/Ubch5C (aqua and orchid)and DNA (blue and gold) PDB code 4r8p

Drag the structure with the mouse to rotate

3D structures of polycomb proteins3D structures of polycomb proteins

Polycomb complex protein 3D structures


ReferencesReferences

  1. ↑ Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C. A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595. doi: 10.1016/j.celrep.2016.08.096. PMID:27705803 doi:http://dx.doi.org/10.1016/j.celrep.2016.08.096
  2. ↑ Poynter ST, Kadoch C. Polycomb and trithorax opposition in development and disease. Wiley Interdiscip Rev Dev Biol. 2016 Nov;5(6):659-688. doi: 10.1002/wdev.244., Epub 2016 Sep 1. PMID:27581385 doi:http://dx.doi.org/10.1002/wdev.244

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Michal Harel, Jaime Prilusky
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