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==Structure of a GPCR-G protein in complex with a natural peptide agonist== | |||
<StructureSection load='8hqc' size='340' side='right'caption='[[8hqc]], [[Resolution|resolution]] 3.89Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8hqc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HQC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.89Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hqc OCA], [https://pdbe.org/8hqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hqc RCSB], [https://www.ebi.ac.uk/pdbsum/8hqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hqc ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: Chami | [https://www.uniprot.org/uniprot/C5AR1_MOUSE C5AR1_MOUSE] Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.[UniProtKB:P21730] | ||
[[Category: | __TOC__ | ||
[[Category: Sarma | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | |||
[[Category: Banerjee R]] | |||
[[Category: Chami M]] | |||
[[Category: Maharana J]] | |||
[[Category: Saha S]] | |||
[[Category: Sarma P]] | |||
[[Category: Shukla AK]] | |||
[[Category: Yadav MK]] | |||
Revision as of 17:08, 18 October 2023
Structure of a GPCR-G protein in complex with a natural peptide agonistStructure of a GPCR-G protein in complex with a natural peptide agonist
Structural highlights
FunctionC5AR1_MOUSE Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.[UniProtKB:P21730] |
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