8hmu: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8hmu is ON HOLD
+==Crystal Structure of PKM2 mutant R516C==
+<StructureSection load='8hmu' size='340' side='right'caption='[[8hmu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors: Upadhyay, S., Kumar, A., Patel, A.K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8hmu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HMU FirstGlance]. <br>
-Description: Crystal Structure of PKM2 mutant R516C
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hmu OCA], [https://pdbe.org/8hmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hmu RCSB], [https://www.ebi.ac.uk/pdbsum/8hmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hmu ProSAT]</span></td></tr>
-[[Category: Upadhyay, S]]
+</table>
-[[Category: Patel, A.K]]
+== Function ==
-[[Category: Kumar, A]]
+[https://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Kumar A]]
+[[Category: Patel AK]]
+[[Category: Upadhyay S]]