5k3y: Difference between revisions

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 == Structural highlights ==
 <table><tr><td colspan='2'>[[5k3y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K3Y FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6Q4:N-METHYL-N-(1-METHYLPIPERIDIN-4-YL)-4-{[4-({(1R,2S)-2-[(PROPAN-2-YL)CARBAMOYL]CYCLOPENTYL}AMINO)-5-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]AMINO}BENZAMIDE'>6Q4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6Q4:N-METHYL-N-(1-METHYLPIPERIDIN-4-YL)-4-{[4-({(1R,2S)-2-[(PROPAN-2-YL)CARBAMOYL]CYCLOPENTYL}AMINO)-5-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]AMINO}BENZAMIDE'>6Q4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k3y OCA], [https://pdbe.org/5k3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k3y RCSB], [https://www.ebi.ac.uk/pdbsum/5k3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k3y ProSAT]</span></td></tr>
 </table>
-== Function ==
-[https://www.uniprot.org/uniprot/AUKBA_XENLA AUKBA_XENLA] Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Phosphorylates 'Ser-10' of histone H3 during mitosis.<ref>PMID:12221116</ref> <ref>PMID:11350965</ref> <ref>PMID:17199039</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==