1iy0: Difference between revisions

Revision as of 14:11, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1iy0.png

Template:STRUCTURE 1iy0

Crystal structure of the FtsH ATPase domain with AMP-PNP from Thermus thermophilusCrystal structure of the FtsH ATPase domain with AMP-PNP from Thermus thermophilus

Template:ABSTRACT PUBMED 12377127

About this StructureAbout this Structure

1IY0 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

ReferenceReference

Hexameric ring structure of the ATPase domain of the membrane-integrated metalloprotease FtsH from Thermus thermophilus HB8., Niwa H, Tsuchiya D, Makyio H, Yoshida M, Morikawa K, Structure. 2002 Oct;10(10):1415-23. PMID:12377127

Page seeded by OCA on Tue Jul 1 14:11:55 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal structure of the FtsH ATPase domain with AMP-PNP from Thermus thermophilus'''
+===Crystal structure of the FtsH ATPase domain with AMP-PNP from Thermus thermophilus===
-==Overview==
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-FtsH is a cytoplasmic membrane-integrated, ATP-dependent metalloprotease, which processively degrades both cytoplasmic and membrane proteins in concert with unfolding. The FtsH protein is divided into the N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. We have determined the crystal structures of the Thermus thermophilus FtsH ATPase domain in the nucleotide-free and AMP-PNP- and ADP-bound states, in addition to the domain with the extra preceding segment. Combined with the mapping of the putative substrate binding region, these structures suggest that FtsH internally forms a hexameric ring structure, in which ATP binding could cause a conformational change to facilitate transport of substrates into the protease domain through the central pore.
+The line below this paragraph, {{ABSTRACT_PUBMED_12377127}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_12377127}}
 ==About this Structure==
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 [[Category: Yoshida, M.]]
 [[Category: Aaa domain fold]]
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