1h8f: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1h8f.gif|left|200px]]<br /> | [[Image:1h8f.gif|left|200px]]<br /><applet load="1h8f" size="450" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1h8f" size="450" color="white" frame="true" align="right" spinBox="true" | |||
caption="1h8f, resolution 2.80Å" /> | caption="1h8f, resolution 2.80Å" /> | ||
'''GLYCOGEN SYNTHASE KINASE 3 BETA.'''<br /> | '''GLYCOGEN SYNTHASE KINASE 3 BETA.'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
1H8F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with EPE as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37] | 1H8F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with EPE as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37] Known structural/functional Site: <scene name='pdbsite=AC1:Epe Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H8F OCA]. | ||
==Reference== | ==Reference== | ||
| Line 22: | Line 21: | ||
[[Category: kinase]] | [[Category: kinase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 16:08:09 2007'' | ||
Revision as of 16:58, 18 December 2007
|
GLYCOGEN SYNTHASE KINASE 3 BETA.
OverviewOverview
Glycogen synthase kinase 3 beta (GSK3 beta) plays a key role in insulin, and Wnt signaling, phosphorylating downstream targets by default, and, becoming inhibited following the extracellular signaling event. The, crystal structure of human GSK3 beta shows a catalytically active, conformation in the absence of activation-segment phosphorylation, with, the sulphonate of a buffer molecule bridging the activation-segment and, N-terminal domain in the same way as the phosphate group of the, activation-segment phospho-Ser/Thr in other kinases. The location of this, oxyanion binding site in the substrate binding cleft indicates direct, coupling of P+4 phosphate-primed substrate binding and catalytic, activation, explains the ability of GSK3 beta to processively, hyperphosphorylate substrates with Ser/Thr pentad-repeats, and suggests a, mechanism for autoinhibition in which the phosphorylated N terminus binds, as a competitive pseudosubstrate with phospho-Ser 9 occupying the P+4, site.
About this StructureAbout this Structure
1H8F is a Single protein structure of sequence from Homo sapiens with EPE as ligand. Active as Transferred entry: 2.7.11.1, with EC number 2.7.1.37 Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition., Dajani R, Fraser E, Roe SM, Young N, Good V, Dale TC, Pearl LH, Cell. 2001 Jun 15;105(6):721-32. PMID:11440715
Page seeded by OCA on Tue Dec 18 16:08:09 2007