7vg7: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7vg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VG7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7vg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VG7 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vg7 OCA], [https://pdbe.org/7vg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vg7 RCSB], [https://www.ebi.ac.uk/pdbsum/7vg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vg7 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vg7 OCA], [https://pdbe.org/7vg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vg7 RCSB], [https://www.ebi.ac.uk/pdbsum/7vg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vg7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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</div> | </div> | ||
<div class="pdbe-citations 7vg7" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 7vg7" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Plexin 3D structures|Plexin 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> |
Latest revision as of 20:24, 29 November 2023
Plexin B1 extracellular fragment in complex with lasso-grafted PB1m6A9 peptidePlexin B1 extracellular fragment in complex with lasso-grafted PB1m6A9 peptide
Structural highlights
FunctionPLXB1_HUMAN Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.[1] [2] [3] [4] [5] [6] Publication Abstract from PubMedSignaling by single-pass transmembrane receptors often involves a formation of ligand-induced receptor dimers with particular conformation, and bivalent receptor binders can modulate receptor functions by inducing different receptor dimer conformations, although such agents are difficult to design. Here, we describe the generation of both antagonistic and agonistic receptor dimerizers toward PlexinB1 (PlxnB1), a receptor for semaphorin 4D (Sema4D), by grafting two different PlxnB1-binding peptides onto the human immunoglobulin G1 (IgG1) Fc protein. The function-modulating activity of a peptide Fc was strongly dependent on the type of the peptide as well as the grafting site, with the best variants showing activity at an nM concentration range. Structural analysis of each peptide-PlxnB1 complex revealed that the agonistic Fc dimerizes PlxnB1 in a face-to-face fashion similar to that induced by Sema4D, whereas antagonistic Fc would induce signaling-incompetent PlxnB1 dimer conformation, enforcing the idea that plexin activation is primarily controlled by the receptor orientation within the dimer. De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function.,Sugano-Nakamura N, Matoba K, Hirose M, Bashiruddin NK, Matsunaga Y, Yamashita K, Hirata K, Yamamoto M, Arimori T, Suga H, Takagi J Structure. 2022 Aug 10. pii: S0969-2126(22)00277-5. doi:, 10.1016/j.str.2022.07.008. PMID:35981535[7] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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