8dwh: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 8dwh is ON HOLD  until Paper Publication
==CryoEM structure of Gq-coupled MRGPRX1 with ligand Compound-16==
 
<StructureSection load='8dwh' size='340' side='right'caption='[[8dwh]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
Authors: Youngfeng, L., Cao, C., Fay, J.F., Roth, B.L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8dwh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DWH FirstGlance]. <br>
Description: CryoEM structure of Gq-coupled MRGPRX1 with ligand Compound-16
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U2U:N-{2-[(1-aminoisoquinolin-6-yl)oxy]-4-methylphenyl}-2-methoxybenzene-1-sulfonamide'>U2U</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dwh OCA], [https://pdbe.org/8dwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dwh RCSB], [https://www.ebi.ac.uk/pdbsum/8dwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dwh ProSAT]</span></td></tr>
[[Category: Cao, C]]
</table>
[[Category: Roth, B.L]]
== Function ==
[[Category: Fay, J.F]]
[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
[[Category: Youngfeng, L]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cao C]]
[[Category: Fay JF]]
[[Category: Liu Y]]
[[Category: Roth BL]]

Revision as of 10:25, 3 November 2022

CryoEM structure of Gq-coupled MRGPRX1 with ligand Compound-16CryoEM structure of Gq-coupled MRGPRX1 with ligand Compound-16

Structural highlights

8dwh is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GBB1_HUMAN Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.[1]

References

  1. ↑ Johnston CA, Kimple AJ, Giguere PM, Siderovski DP. Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2. Structure. 2008 Jul;16(7):1086-94. PMID:18611381 doi:http://dx.doi.org/10.1016/j.str.2008.04.010

8dwh, resolution 3.25Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=8dwh&oldid=3655900"