8dwc: Difference between revisions
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==CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22== | |||
<StructureSection load='8dwc' size='340' side='right'caption='[[8dwc]], [[Resolution|resolution]] 2.87Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8dwc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DWC FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dwc OCA], [https://pdbe.org/8dwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dwc RCSB], [https://www.ebi.ac.uk/pdbsum/8dwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dwc ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: Cao | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/PENK_BOVIN PENK_BOVIN] Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.[UniProtKB:P01210] Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.[UniProtKB:P01210] Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release.[UniProtKB:P22005] Increases glutamate release in the striatum and decreases GABA concentration in the striatum.[UniProtKB:P04094] Increases glutamate release in the striatum.[UniProtKB:P04094] Enkelytin possesses antibacterial activity against Gram-positive bacteria such as Micrococcus luteus and Bacillus megaterium.<ref>PMID:8654396</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bos taurus]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Cao C]] | |||
[[Category: Fay JF]] | |||
[[Category: Liu Y]] | |||
[[Category: Roth BL]] | |||
Revision as of 10:25, 3 November 2022
CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22
Structural highlights
FunctionPENK_BOVIN Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.[UniProtKB:P01210] Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.[UniProtKB:P01210] Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release.[UniProtKB:P22005] Increases glutamate release in the striatum and decreases GABA concentration in the striatum.[UniProtKB:P04094] Increases glutamate release in the striatum.[UniProtKB:P04094] Enkelytin possesses antibacterial activity against Gram-positive bacteria such as Micrococcus luteus and Bacillus megaterium.[1] References
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