1ilg: Difference between revisions

Revision as of 13:27, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1ilg.png

Template:STRUCTURE 1ilg

Crystal Structure of Apo Human Pregnane X Receptor Ligand Binding DomainCrystal Structure of Apo Human Pregnane X Receptor Ligand Binding Domain

Template:ABSTRACT PUBMED 11408620

About this StructureAbout this Structure

1ILG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity., Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR, Science. 2001 Jun 22;292(5525):2329-33. Epub 2001 Jun 14. PMID:11408620

Page seeded by OCA on Tue Jul 1 13:27:45 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal Structure of Apo Human Pregnane X Receptor Ligand Binding Domain'''
+===Crystal Structure of Apo Human Pregnane X Receptor Ligand Binding Domain===
-==Overview==
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-The human nuclear pregnane X receptor (hPXR) activates cytochrome P450-3A expression in response to a wide variety of xenobiotics and plays a critical role in mediating dangerous drug-drug interactions. We present the crystal structures of the ligand-binding domain of hPXR both alone and in complex with the cholesterol-lowering drug SR12813 at resolutions of 2.5 and 2.75 angstroms, respectively. The hydrophobic ligand-binding cavity of hPXR contains a small number of polar residues, permitting SR12813 to bind in three distinct orientations. The position and nature of these polar residues were found to be critical for establishing the precise pharmacologic activation profile of PXR. Our findings provide important insights into how hPXR detects xenobiotics and may prove useful in predicting and avoiding drug-drug interactions.
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+{{ABSTRACT_PUBMED_11408620}}
 ==About this Structure==
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 [[Category: Promiscuous]]
 [[Category: Xenobiotic]]
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