1ig3: Difference between revisions

Revision as of 10:55, 1 July 2008

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File:1ig3.png

Template:STRUCTURE 1ig3

Mouse Thiamin Pyrophosphokinase Complexed with ThiaminMouse Thiamin Pyrophosphokinase Complexed with Thiamin

Template:ABSTRACT PUBMED 11419946

About this StructureAbout this Structure

1IG3 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of thiamin pyrophosphokinase., Timm DE, Liu J, Baker LJ, Harris RA, J Mol Biol. 2001 Jun 29;310(1):195-204. PMID:11419946

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-'''Mouse Thiamin Pyrophosphokinase Complexed with Thiamin'''
+===Mouse Thiamin Pyrophosphokinase Complexed with Thiamin===
-==Overview==
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-Thiamin pyrophosphate (TPP) is a coenzyme derived from vitamin B1 (thiamin). TPP synthesis in eukaryotes requires thiamin pyrophosphokinase (TPK), which catalyzes the transfer of a pyrophosphate group from ATP to thiamin. TPP is essential for central metabolic processes, including the formation of acetyl CoA from glucose and the Krebs cycle. Deficiencies in human thiamin metabolism result in beriberi and Wernicke encephalopathy. The crystal structure of mouse TPK was determined by multiwavelength anomalous diffraction at 2.4 A resolution, and the structure of TPK complexed with thiamin has been refined at 1.9 A resolution. The TPK polypeptide folds as an alpha/beta-domain and a beta-sandwich domain, which share a central ten-stranded mixed beta-sheet. TPK subunits associate as a dimer, and thiamin is bound in the dimer interface. Despite lacking apparent sequence homology with other proteins, the alpha/beta-domain resembles the Rossman fold and is similar to other kinase structures, including another pyrophosphokinase and a thiamin biosynthetic enzyme. Comparison of mouse and yeast TPK structures reveals differences that could be exploited in developing species-specific inhibitors of potential use as antimicrobial agents.
+The line below this paragraph, {{ABSTRACT_PUBMED_11419946}}, adds the Publication Abstract to the page
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