1if1: Difference between revisions

Revision as of 10:52, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1if1.png

Template:STRUCTURE 1if1

INTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNAINTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNA

Template:ABSTRACT PUBMED 9422515

About this StructureAbout this Structure

1IF1 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structure of IRF-1 with bound DNA reveals determinants of interferon regulation., Escalante CR, Yie J, Thanos D, Aggarwal AK, Nature. 1998 Jan 1;391(6662):103-6. PMID:9422515

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-'''INTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNA'''
+===INTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNA===
-==Overview==
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-The family of interferon regulatory factor (IRF) transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Here we report the crystal structure of the IRF-1 region bound to the natural positive regulatory domain I (PRD I) DNA element from the interferon-beta promoter. The structure provides the first three-dimensional view of a member of the growing IRF family, revealing a new helix-turn-helix motif that latches onto DNA through three of the five conserved tryptophans. The motif selects a short GAAA core sequence through an obliquely angled recognition helix, with an accompanying bending of the DNA axis in the direction of the protein. Together, these features suggest a basis for the occurrence of GAAA repeats within IRF response elements and provide clues to the assembly of the higher-order interferon-beta enhancesome.
+The line below this paragraph, {{ABSTRACT_PUBMED_9422515}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_9422515}}
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 [[Category: Interferon regulation]]
 [[Category: Transcription factor]]
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