4cwt: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CWT FirstGlance]. <br> | <table><tr><td colspan='2'>[[4cwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CWT FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IK9:2-{[(2Z)-5-(1,3-BENZODIOXOL-5-YLMETHYL)-8-FLUORO-2-IMINO-2,3-DIHYDRO[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-10-YL]AMINO}ETHANOL'>IK9</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IK9:2-{[(2Z)-5-(1,3-BENZODIOXOL-5-YLMETHYL)-8-FLUORO-2-IMINO-2,3-DIHYDRO[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-10-YL]AMINO}ETHANOL'>IK9</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwt OCA], [https://pdbe.org/4cwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cwt RCSB], [https://www.ebi.ac.uk/pdbsum/4cwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwt ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwt OCA], [https://pdbe.org/4cwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cwt RCSB], [https://www.ebi.ac.uk/pdbsum/4cwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||