1idz: Difference between revisions

Revision as of 10:49, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1idz.png

Template:STRUCTURE 1idz

STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, 20 STRUCTURESSTRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 8942977

About this StructureAbout this Structure

1IDZ is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

ReferenceReference

A small engineered protein lacks structural uniqueness by increasing the side-chain conformational entropy., Furukawa K, Oda M, Nakamura H, Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13583-8. PMID:8942977

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, 20 STRUCTURES'''
+===STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, 20 STRUCTURES===
-==Overview==
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-A small globular protein, the third repeat of the c-Myb DNA-binding domain, which is composed of 54 amino acid residues, was engineered so as to understand the structural uniqueness of native proteins. This small protein has three alpha-helices that form a helix-turn-helix structure, which is maintained by the hydrophobic core with three Ile residues. One of the mutant proteins, with two of the buried Ile (Ile-155 and Ile-181) substituted with Leu residues, showed multiple conformations, as monitored by heteronuclear magnetic resonance spectroscopy for 13C- and 15N-labeled proteins. The increase in the side-chain conformational entropy, caused by changing the Ile to a Leu residue on an alpha-helix, could engender the lack of structural uniqueness. In native proteins, the conformations of not only the beta-branched side chains, but also those of the neighboring bulky side chains, can be greatly restricted, depending upon the local backbone structure.
+The line below this paragraph, {{ABSTRACT_PUBMED_8942977}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8942977 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8942977}}
 ==About this Structure==
-IDZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IDZ OCA].
+IDZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IDZ OCA].
 ==Reference==
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 [[Category: Dna-binding protein]]
 [[Category: Protooncogene product]]
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