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| [[Image:1iak.gif|left|200px]] | | {{Seed}} |
| | [[Image:1iak.png|left|200px]] |
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| {{STRUCTURE_1iak| PDB=1iak | SCENE= }} | | {{STRUCTURE_1iak| PDB=1iak | SCENE= }} |
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| '''HISTOCOMPATIBILITY ANTIGEN I-AK'''
| | ===HISTOCOMPATIBILITY ANTIGEN I-AK=== |
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| ==Overview==
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| We have determined the structure of murine MHC class II I-Ak in complex with a naturally processed peptide from hen egg lysozyme (HEL residues 50-62) at 1.9 A resolution. These results provide a structural basis for the I-Ak peptide-binding motif. Binding is established by the deep burial of five anchor side chains into specific pockets of the I-Ak binding groove, with a zen-like fit of an aspartic acid in the P1 pocket. We also show that in the I-Ak alpha chain, a bulge occurs in the first strand of the peptide-binding platform, an insertion probably common to all I-A and HLA-DQ alleles. The I-Ak beta chain has a deletion in the helical region adjacent to the P7 pocket and an insertion in the helical region neighboring the P1 pocket. As a result of these structural features, the extended HEL peptide dips low into the center of the I-Ak groove and reaches toward solvent at its C-terminal end.
| | The line below this paragraph, {{ABSTRACT_PUBMED_9529148}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9529148 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9529148}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Mhc]] | | [[Category: Mhc]] |
| [[Category: Peptide complex]] | | [[Category: Peptide complex]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:46:29 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:40:16 2008'' |