4b70: Difference between revisions

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 <StructureSection load='4b70' size='340' side='right'caption='[[4b70]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4b70]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B70 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4b70]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B70 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WM9:(2S)-2-[3-(3-CHLOROPHENYL)PHENYL]-2-METHYL-5,6-DIHYDRO-1,3-OXAZIN-4-AMINE'>WM9</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fkn|1fkn]], [[1m4h|1m4h]], [[1py1|1py1]], [[1sgz|1sgz]], [[1tqf|1tqf]], [[1ujj|1ujj]], [[1ujk|1ujk]], [[1w50|1w50]], [[1w51|1w51]], [[1xn2|1xn2]], [[1xn3|1xn3]], [[1xs7|1xs7]], [[1ym2|1ym2]], [[1ym4|1ym4]], [[2b8l|2b8l]], [[2b8v|2b8v]], [[2fdp|2fdp]], [[2va5|2va5]], [[2va6|2va6]], [[2va7|2va7]], [[2vie|2vie]], [[2vij|2vij]], [[2viy|2viy]], [[2viz|2viz]], [[2vj6|2vj6]], [[2vj7|2vj7]], [[2vj9|2vj9]], [[2vkm|2vkm]], [[2vnm|2vnm]], [[2vnn|2vnn]], [[2wez|2wez]], [[2wf0|2wf0]], [[2wf1|2wf1]], [[2wf2|2wf2]], [[2wf3|2wf3]], [[2wf4|2wf4]], [[2wjo|2wjo]], [[2xfi|2xfi]], [[2xfj|2xfj]], [[2xfk|2xfk]], [[4acu|4acu]], [[4acx|4acx]], [[4azy|4azy]], [[4b00|4b00]], [[4b05|4b05]], [[4b0q|4b0q]], [[4b1c|4b1c]], [[4b1d|4b1d]], [[4b1e|4b1e]], [[4b72|4b72]], [[4b77|4b77]], [[4b78|4b78]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WM9:(2S)-2-[3-(3-CHLOROPHENYL)PHENYL]-2-METHYL-5,6-DIHYDRO-1,3-OXAZIN-4-AMINE'>WM9</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b70 OCA], [https://pdbe.org/4b70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b70 RCSB], [https://www.ebi.ac.uk/pdbsum/4b70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b70 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
+[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Memapsin 2]]
+[[Category: Berg S]]
-[[Category: Berg, S]]
+[[Category: Blid J]]
-[[Category: Blid, J]]
+[[Category: Eketjall S]]
-[[Category: Eketjall, S]]
+[[Category: Falting J]]
-[[Category: Falting, J]]
+[[Category: Ginman T]]
-[[Category: Ginman, T]]
+[[Category: Gravenfors Y]]
-[[Category: Gravenfors, Y]]
+[[Category: Janson J]]
-[[Category: Janson, J]]
+[[Category: Jeppsson F]]
-[[Category: Jeppsson, F]]
+[[Category: Johansson P]]
-[[Category: Johansson, P]]
+[[Category: Karlstrom S]]
-[[Category: Karlstrom, S]]
+[[Category: Kieseritzky F]]
-[[Category: Kieseritzky, F]]
+[[Category: Kihlstrom J]]
-[[Category: Kihlstrom, J]]
+[[Category: Kolmodin K]]
-[[Category: Kolmodin, K]]
+[[Category: Lindstrom J]]
-[[Category: Lindstrom, J]]
+[[Category: Olsson L]]
-[[Category: Olsson, L]]
+[[Category: Rahm F]]
-[[Category: Rahm, F]]
+[[Category: Slivo C]]
-[[Category: Slivo, C]]
+[[Category: Stromberg K]]
-[[Category: Stromberg, K]]
+[[Category: Swahn B]]
-[[Category: Swahn, B]]
+[[Category: Viklund J]]
-[[Category: Viklund, J]]
-[[Category: Hydrolase]]
-[[Category: Hydrolase inhibitor]]
-[[Category: Lead generation]]
-[[Category: Structure-based drug design]]