7rzf: Difference between revisions
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==== | ==Insulin Degrading Enzyme O/pC== | ||
<StructureSection load='7rzf' size='340' side='right'caption='[[7rzf]]' scene=''> | <StructureSection load='7rzf' size='340' side='right'caption='[[7rzf]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7rzf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RZF FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rzf OCA], [https://pdbe.org/7rzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rzf RCSB], [https://www.ebi.ac.uk/pdbsum/7rzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rzf ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rzf OCA], [https://pdbe.org/7rzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rzf RCSB], [https://www.ebi.ac.uk/pdbsum/7rzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rzf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Liang WG]] | ||
[[Category: Mancl JM]] | |||
[[Category: Tang WJ]] | |||