4aw2: Difference between revisions

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 <StructureSection load='4aw2' size='340' side='right'caption='[[4aw2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4aw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AW2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4aw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AW2 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=22E:5,11-DIMETHYL-1-OXO-2,6-DIHYDRO-1H-PYRIDO[4,3-B]CARBAZOL-9-YL+BENZOATE'>22E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=22E:5,11-DIMETHYL-1-OXO-2,6-DIHYDRO-1H-PYRIDO[4,3-B]CARBAZOL-9-YL+BENZOATE'>22E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aw2 OCA], [https://pdbe.org/4aw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aw2 RCSB], [https://www.ebi.ac.uk/pdbsum/4aw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aw2 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/MRCKA_RAT MRCKA_RAT]] Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.<ref>PMID:18854160</ref> <ref>PMID:21457715</ref> <ref>PMID:9418861</ref>
+[https://www.uniprot.org/uniprot/MRCKA_RAT MRCKA_RAT] Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.<ref>PMID:18854160</ref> <ref>PMID:21457715</ref> <ref>PMID:9418861</ref>
 ==See Also==
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 __TOC__
 </StructureSection>
-[[Category: Buffalo rat]]
 [[Category: Large Structures]]
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Rattus norvegicus]]
-[[Category: Azeez, K Abdul]]
+[[Category: Abdul Azeez K]]
-[[Category: Bountra, C]]
+[[Category: Bountra C]]
-[[Category: Delft, F von]]
+[[Category: Edwards A]]
-[[Category: Edwards, A]]
+[[Category: Elkins JM]]
-[[Category: Elkins, J M]]
+[[Category: Knapp S]]
-[[Category: Knapp, S]]
+[[Category: Lafanechere L]]
-[[Category: Lafanechere, L]]
+[[Category: Leung T]]
-[[Category: Leung, T]]
+[[Category: Muniz JRC]]
-[[Category: Muniz, J R.C]]
+[[Category: Phillips C]]
-[[Category: Phillips, C]]
+[[Category: Prudent R]]
-[[Category: Prudent, R]]
+[[Category: Szklarz M]]
-[[Category: Szklarz, M]]
+[[Category: Tan I]]
-[[Category: Tan, I]]
+[[Category: Wang J]]
-[[Category: Wang, J]]
+[[Category: Von Delft F]]
-[[Category: Cdc42bpa]]
-[[Category: Transferase]]