4aa2: Difference between revisions

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 <StructureSection load='4aa2' size='340' side='right'caption='[[4aa2]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4aa2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AA2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4aa2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Gloydius_blomhoffii Gloydius blomhoffii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AA2 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2x94|2x94]], [[1j38|1j38]], [[2x8z|2x8z]], [[1j36|1j36]], [[2xhm|2xhm]], [[2x8y|2x8y]], [[2x91|2x91]], [[2x95|2x95]], [[2x96|2x96]], [[2x92|2x92]], [[2x97|2x97]], [[2x93|2x93]], [[3zqz|3zqz]], [[2x90|2x90]], [[1j37|1j37]], [[4aa1|4aa1]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aa2 OCA], [https://pdbe.org/4aa2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aa2 RCSB], [https://www.ebi.ac.uk/pdbsum/4aa2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aa2 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/ACE_DROME ACE_DROME]] May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.<ref>PMID:12591244</ref>  [[https://www.uniprot.org/uniprot/BNP_GLOBL BNP_GLOBL]] Blomhotin: inhibits the rabbit lung angiotensin-converting enzyme (ACE) with an IC(50) of 15 uM.  Bradykinin-potentiating peptide A: causes no contraction of the rat gastric fundus smooth muscle even at high concentrations.  Bradykinin-potentiating peptide B: inhibits the activity of the angiotensin-converting enzyme (ACE) by a preferential interaction with its C-domain. Also potentiates the hypotensive effects of bradykinin. Inhibits the rabbit lung ACE with an IC(50) of 1.1 uM.  Bradykinin-potentiating peptide C: inhibits the activity of the angiotensin-converting enzyme (ACE) by interacting with the same potency to its C- and N-domains (PubMed:11994001). Inhibits the rabbit lung angiotensin-converting enzyme (ACE) with an IC(50) of 7.1 uM.<ref>PMID:11994001</ref>   Leu3-blomhotin: inhibits the rabbit lung angiotensin-converting enzyme (ACE) with an IC(50) of 46 uM. Synthetic Leu3-blomhotin contracts the rat gastric fundus smooth muscle in a rapid and transient manner.  Bradykinin-potentiating peptide Ahb1: potentiates the bradykinin in vivo.  Bradykinin-potentiating peptide Ahb2: does not show any bradykinin-potentiating effects.  C-type natriuretic peptide: exhibits hypotensive and vasodepressor activity. Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3) (By similarity).
+[https://www.uniprot.org/uniprot/ACE_DROME ACE_DROME] May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.<ref>PMID:12591244</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Drome]]
+[[Category: Drosophila melanogaster]]
+[[Category: Gloydius blomhoffii]]
 [[Category: Large Structures]]
-[[Category: Peptidyl-dipeptidase A]]
+[[Category: Acharya KR]]
-[[Category: Acharya, K R]]
+[[Category: Akif M]]
-[[Category: Akif, M]]
+[[Category: Isaac RE]]
-[[Category: Isaac, R E]]
+[[Category: Masuyer G]]
-[[Category: Masuyer, G]]
+[[Category: Schwager SLU]]
-[[Category: Schwager, S L.U]]
+[[Category: Sturrock ED]]
-[[Category: Sturrock, E D]]
-[[Category: Hydrolase]]
-[[Category: Hydrolase-peptide complex]]
-[[Category: Inhibitor]]
-[[Category: Substrate binding]]